Fig. 8
Simulation of in vivo experiments for the detectability of diseased tissue. The gray areas illustrate the true T1ρ values for healthy (light gray) and diseased tissue (dark gray). A natural variation of ± 1% was assumed in the simulation for the N = 1000 random experiments. The uncorrected fit results (red) and the corrected fit results (blue) were compared. In A, the impact of radiofrequency (RF) flip angle choice (α = 10–40°) on quantification accuracy and significance levels at 5% increased T1ρ in diseased tissue was investigated. In B the sensitivity of detectability for increased T1ρ in the range 1–4% was investigated for α = 40°. The corrected fit provides consistent results for all simulated RF flip angles (p < 0.001) and improved detection sensitivity for increased T1ρ (p < 0.05 for + 2%)