Fig. 9
Simulation of in vivo experiments for the detectability of diseased tissue. The gray areas illustrate the true T1ρ values for healthy (light gray) and diseased tissue (dark gray). A natural variation of ± 1% was assumed in the simulation for the N = 1000 random experiments. For the RF flip angle α = 40° was used. The impact of varying T1 values in diseased tissue on T1ρ quantification and detectability was investigated. A 5% increased T1ρ in diseased tissue was considered. In A, the uncorrected fit results (red) and the corrected fit results (blue) were compared. Here, the correction was performed using the baseline T1 value (1400 ms) for both healthy and diseased tissue. In (B), the corrected fit using the true T1 values of healthy and diseased tissue was supplemented. The results show significantly improved detectability based on the corrected fit (A). Using true T1 values instead of baseline values, the quantification accuracy can be slightly increased (B)