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Table 1 Demographic, clinical, and CMR characteristics in all subjects

From: Multiparametric mapping by cardiovascular magnetic resonance imaging in cardiac tumors

Parameters

Benign cardiac tumors (n = 54)

Primary cardiac malignant tumors (n = 26)

Control subjects (n = 50)

Age, years

52 (34–65)

48 (30–57)

51 (42–60)

Males, n (%)

22 (41)‡

11 (42)*

24 (48)

BMI, kg/m2

22.9 ± 5.8

21.5 ± 4.8

22.4 (20.8–25.2)

SBP, mmHg

126 ± 17.3

108 ± 11.8*

122.4 ± 10.3

DBP, mmHg

81.4 ± 11.1

70.5 ± 10.4*

74.3 ± 7.8

Heart rate

83.0 ± 15.5‡

96.5 ± 17.9*‡

75.3 ± 9.6

Hct

0.39 ± 0.07‡

0.35 ± 0.08*‡

0.43 ± 0.03

cTnT, g/L

12.2 (7.0–45.7)

12.1 (9.8–22.2)

–

NT-proBNP, pg/mL

245 (57–871)

515 (295–1954)

–

AFP

2.2 (1.7–3.0)

2.4 (1.8–3.7)

–

CEA

1.7 (0.7–2.7)

1.4 (0.7–3.2)

–

CA19-9

9.9 (3.7–17.7)

7.4 (5.4–12.8)

–

CA125

21.0 (11.0–45.1)

150 (32.5–457)*

–

Cardiac structure and function

 LVEDVi, mL/m2

75.3 ± 20.2

68.4 ± 25.4

76.6 ± 12.2

 LVESVi, mL/m2

30.5 ± 12.1

28.0 ± 10.8

28.5 ± 7.4

 LVEF, %

59.7 ± 9.2

59.0 ± 7.6

63.4 ± 5.3

 LVmassi, g/m2

63.4 ± 26.1

60.5 ± 30.4

45.5 ± 8.2

 RVEDVi, mL/m2

67.2 ± 18.6

66.7 ± 36.4

70.7 ± 16.5

 RVESVi, mL/m2

35.6 ± 17.7

33.3 ± 21.7

31.7 ± 10.3

 RVEF, %

53.9 ± 11.0

53.6 ± 10.6

57.2 ± 14.2

Characteristics of tumors

 Location

  LA, n (%)

14 (26)

4 (15)

–

  RA, n (%)

16 (30)

12 (46)

–

  LV, n (%)

11 (20)

2 (8)

–

  RV, n (%)

11 (20)

7 (27)

–

  Valves, n (%)

2 (4)

1 (4)

–

 Mobility, n (%)

37 (69)

4 (15)*

–

 Invasiveness, n (%)

3 (6)

20 (77)*

–

 Irregular border, n (%)

10 (19)

16 (62)*

–

 Longest diameter, cm

3.3 (1.9–4.6)

6.5 (4.4–7.4)*

–

 Shortest diameter, cm

2.0 (1.3–3.0)

3.2 (2.4–4.9)*

–

 Pericardial effusion, n (%)

6 (11)

13 (54)*

–

 Tissue characteristics

  T1-weighted, n (%)

   Hypointense

3 (6)

2 (3)

–

   Isointense

48 (89)

21 (81)

–

   Hyperintense

3 (6)

3 (12)

–

  T2-weighted, n (%)

   Hypointense

3 (6)

2 (3)

–

   Isointense

13 (24)

9 (35)

–

   Hyperintense

38 (70)

15 (58)

–

  First-pass perfusion, n (%)

   None

2 (4)

0 (0)

–

   Hypoperfusion

32 (59)

13 (50)

–

   Isoperfusion

8(15)

7 (27)

–

   Hyperperfusion

12 (22)

6 (23)

–

  LGE

   None

14 (26)

3 (12)

–

   Homogeneous

13 (24)

3 (12)

–

   Heterogeneous

27 (50)

20 (77)

–

  Mapping parameters

   T1 mapping (pre)-mass, msa

1684 ± 450

1627 ± 410

–

   T1 mapping (post)-mass, msa

433 ± 123

412 ± 135

–

   T2 mapping-mass, msa

59 ± 25

63 ± 34

–

Tissue characteristics of myocardium

 T1 mapping (pre-contrast)

  T1 mapping-mean, ms

1260 ± 46‡

1360 ± 61*‡

1206 ± 44

  T1 mapping-peri, ms

1266 ± 47

1388 ± 96*

–

  T1 mapping-remote, ms

1253 ± 51

1337 ± 67*

–

 T1 mapping (post-contrast)

  T1 mapping-mean, ms

536 ± 63‡

544 ± 83‡

503 ± 52

  T1 mapping-peri, ms

546 ± 66

540 ± 82

–

  T1 mapping-remote, ms

544 ± 63

577 ± 75

–

 T2 mapping

  T2 mapping-mean, ms

41 ± 3.0‡

42 ± 3.2‡

38 ± 3.1

  T2 mapping-peri, ms

40 ± 3.1

42 ± 3.2

–

  T2 mapping-remote, ms

41 ± 3.0

41 ± 3.7

–

 ECV

  ECV-mean, %

30 ± 2.5‡

35 ± 5.2*‡

27 ± 3.0

  ECV-peri, %

29 ± 3.0

36 ± 6.9*

–

  ECV-remote, %

29 ± 2.7

33 ± 5.8*

–

 LGE

  Presence, n (%)

0

3 (12%)

–

  1. Abnormally distributed variables were presented as median with interquartile range and compared using the Mann–Whitney U test
  2. CMR cardiovascular magnetic resonance, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, Hct haematocrit, cTNT cardiac troponin T, NT-proBNP N-terminal pro-B-type natriuretic peptide, AFP alpha-fetoprotein, CEA carcinoembryonic antigen, CA19-9 cancer antigen 19-9, CA125 cancer antigen 125, LVEDVi left ventricular end-diastolic volume index, LVESVi left ventricular end-systolic volume index, LVEF left ventricular ejection fraction, LVmassi left ventricular mass index, RVEDVi right ventricular end-diastolic volume index, RVESVi right ventricular end-systolic volume index, RVEF right ventricular ejection fraction, LA left atrium, RA right atrium, LV left ventricle, RV right ventricle
  3. *P value indicates significant difference between benign and primary malignant cardiac tumors
  4. ‡P value indicates significant difference in the mean myocardial values compared with normal controls
  5. aThe data are obtained from patients with mapping values on cardiac mass